Cutting Edge: Memory Regulatory T Cells Require IL-7 and Not IL-2 for Their Maintenance in Peripheral Tissues
作者： Iris K. Gratz , Hong-An Truong , Sara Hsin-Yi Yang , Megan M. Maurano , Karim Lee
关键词: Hair follicle 、 TCIRG1 、 Biology 、 Immunology 、 Cytotoxic T cell 、 IL-2 receptor 、 Cell biology 、 Antigen 、 Interleukin 21 、 Antigen-presenting cell 、 Interleukin 3
摘要: Thymic Foxp3-expressing regulatory T cells are activated by peripheral self-antigen to increase their suppressive function, and a fraction of these survive as memory (mTregs). mTregs persist in nonlymphoid tissue after cessation Ag expression have enhanced capacity suppress tissue-specific autoimmunity. In this study, we show that murine express specific effector cell markers localize preferentially hair follicles skin. Memory Tregs high levels both IL-2Rα IL-7Rα. Using genetic-deletion approach, IL-2 is required generate from naive CD4+ precursors vivo. However, not maintain the skin skin-draining lymph nodes. Conversely, IL-7 essential for maintaining steady state. These results elucidate fundamental biology plays an important role survival
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