Interleukin-7 Optimizes FOXP3+CD4+ Regulatory T Cells Reactivity to Interleukin-2 by Modulating CD25 Expression

摘要: The vast majority of Foxp3 regulatory T cells (Treg) exhibits constitutive expression CD25 (IL-2Rα), which allows the constitution high affinity IL-2Rαβγ receptor, ensuring efficient IL-2 binding by Treg. Maintenance at Treg surface depends on both cell intrinsic factors and environmental stimuli such as itself. Whether other can participate to maintenance in vivo is present unknown. In work we demonstrated that IL-7, a gamma-chain cytokine exerting crucial role development homeostasis, able necessary sustain levels surface. We that, during vitro cultures performed absence IL-2, IL-7 through transcriptional mechanism. By studying mice signaling either genetically impaired or increased employing adoptive transfer murine models, for sustained vivo. To ascertain biological impact mediated modulation expression, affected their ability efficiently bind transduce signaling. Finally, dependent associated with potentiated induced expansion Collectively, our results identify factor contributing thereby affecting react IL-2.