Direct effects of interleukin-7 on the function of human T cells in vitro.
作者： Vyacheslav A Shmarov , Vladimir V Malashchenko , Maksim E Meniailo , Natalia D Gazatova , Natalia M Todosenko
关键词:
摘要: СD3+ T lymphocytes were isolated by positive magnetic separation from the peripheral blood of healthy donors. In absence any additional activating stimuli, interleukin-7 (IL-7) was shown to augment levels cells expressing CD25 activation marker both in СD4-positive and CD4-negative effector memory (CD45RA-CD197-) cell subsets, as well terminally differentiated (CD45RA+CD197-) Т cells, without significantly affecting status naive (CD45RA+CD197+) central (CD45RA-CD197+) cells. addition, IL-7 noticeably enhanced production IL-2, interferon-γ (IFN-γ), IL-10, but not IL-4, The direct effects on induced vitro MACSiBead™ particles coated with CD2, CD3, CD28 antibodies (Abs) also investigated. Upon activation, augmented CD25+ (CD45RA+CD197+), (CD45RA-CD197+), T-cell compartments. facilitated СD4- (but CD4+) Finally, found upregulate IFN-γ, IL-10 activated conclusion, we speculate that is capable enhancing functional activity causing significant inbalance between various subsets.
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