Naive CD4+ T cells can be sensitized with IL-7.
作者： J. Vakkila , S. Äystö , U. M. Saarinen-Pihkala , H. Sariola
DOI: 10.1046/J.1365-3083.2001.01001.X
关键词:
摘要: We addressed the question whether it is possible to lower threshold for naive T cells respond antigens. Purified adult and cord blood derived CD4+ CD45RA+ were incubated in presence of various cytokines two days (‘primed cells’), after which removed by extensive washing. Primed unprimed activated with solid phase-coupled anti-CD3 soluble anti-CD28 monoclonal antibodies (MoAb). Naive cells, primed interleukin(IL)-7 proliferated more vigorously than cells. required 6 h antigenic stimulation, whereas 20 h. The priming also shifted order stimulate antigen concentration a level. addition IL-10 almost completely abrogated enhancing effect IL-7 on Other (IL-1, IL-2, IL-6, IL-12, interferon (IFN)-γ, tumour necrosis factor (TNF)-α had less cell proliferation. However, no impact proliferation allogeneic immature or mature dendritic (DC). conclude that antigen-independent activation prior stimulation sensitizes may be help trying immune responses against weak This approach, however, does not enhance proliferative stimulated DC.
sci-hub.se 参考文章(19)
Hervé Groux, Anne O'Garra, Mike Bigler, Matthieu Rouleau, Svetlana Antonenko, Jan E. de Vries, Maria Grazia Roncarolo, A CD4 + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis Nature. ,vol. 389, pp. 737- 742 ,(1997) , 10.1038/39614
S L Swain, M Croft, C Dubey, Naive and effector CD4 T cells differ in their requirements for T cell receptor versus costimulatory signals. Journal of Immunology. ,vol. 157, pp. 3280- 3289 ,(1996)
J E de Vries, R de Waal Malefyt, H Yssel, Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation. Journal of Immunology. ,vol. 150, pp. 4754- 4765 ,(1993)
D. A. Taylor-Fishwick, B. M. J. Foxwell, T. H. Page, J. L. Willcocks, Characterization of a novel high affinity human IL-7 receptor. Expression on T cells and association with IL-7 driven proliferation. Journal of Immunology. ,vol. 151, pp. 4753- 4763 ,(1993)
Jacques Banchereau, Ralph M. Steinman, Dendritic cells and the control of immunity Nature. ,vol. 392, pp. 245- 252 ,(1998) , 10.1038/32588
C. G. Sagerstrom, E. M. Kerr, J. P. Allison, M. M. Davis, Activation and differentiation requirements of primary T cells in vitro. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 8987- 8991 ,(1993) , 10.1073/PNAS.90.19.8987
Derya Unutmaz, Fabiana Baldoni, Sergio Abrignani, HUMAN NAIVE T CELLS ACTIVATED BY CYTOKINES DIFFERENTIATE INTO A SPLIT PHENOTYPE WITH FUNCTIONAL FEATURES INTERMEDIATE BETWEEN NAIVE AND MEMORY T CELLS International Immunology. ,vol. 7, pp. 1417- 1424 ,(1995) , 10.1093/INTIMM/7.9.1417
Claire L. Amos, Anders Woetmann, Mette Nielsen, Carsten Geisler, Niels Ødum, Barry L. Brown, Pauline R.M. Dobson, THE ROLE OF CASPASE 3 AND BclxLIN THE ACTION OF INTERLEUKIN 7 (IL-7): A SURVIVAL FACTOR IN ACTIVATED HUMAN T CELLS Cytokine. ,vol. 10, pp. 662- 668 ,(1998) , 10.1006/CYTO.1998.0351
LMC Webb, BMJ Foxwell, M Feldmann, None, Putative role for interleukin-7 in the maintenance of the recirculating naive CD4+ T-cell pool. Immunology. ,vol. 98, pp. 400- 405 ,(1999) , 10.1046/J.1365-2567.1999.00906.X
Giandomenica Iezzi, Klaus Karjalainen, Antonio Lanzavecchia, The Duration of Antigenic Stimulation Determines the Fate of Naive and Effector T Cells Immunity. ,vol. 8, pp. 89- 95 ,(1998) , 10.1016/S1074-7613(00)80461-6