Tertiary lymphoid structures, drivers of the anti‐tumor responses in human cancers

摘要: The characterization of the microenvironment human tumors led to description tertiary lymphoid structures (TLS) characterized by mature dendritic cells in a T-cell zone adjacent B-cell follicle including germinal center. TLS represent sites neogenesis that develop most solid cancers. Analysis current literature shows presence is associated with favorable clinical outcome for cancer patients, regardless approach used quantify and stage disease. Using several approaches combine immunohistochemistry, gene expression assays, flow cytometry on large series lung tumors, our work demonstrated are important initiation and/or maintenance local systemic T- responses against tumors. Surrounded high endothelial venules, they privileged area recruitment lymphocytes into generation central-memory T B circulate limit progression. can be considered as novel biomarker stratify overall survival risk untreated patients marker efficient immunotherapies. induction manipulation cancer-associated using drug agonists biotherapies should open new avenues treat patients.