CD4 + CD25 + Foxp3 + regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4 + T cells
作者： Pushpa Pandiyan , Lixin Zheng , Satoru Ishihara , Jennifer Reed , Michael J Lenardo
DOI: 10.1038/NI1536
关键词:
摘要: A key issue in mammalian immunology is how CD4+CD25+Foxp3+ regulatory T cells (T(reg) cells) suppress immune responses. Here we show that T(reg) induced apoptosis of effector CD4+ vitro and vivo a mouse model inflammatory bowel disease. did not affect the early activation or proliferation cells. Cytokines signal through common gamma-chain suppressed cell-induced apoptosis. cell death required proapoptotic protein Bim, incubated with showed less prosurvival kinase Akt phosphorylation Bad. Thus, cytokine deprivation-induced prominent mechanism by which inhibit
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