Regulatory T-cells, FoxP3 and atherosclerosis.
作者： Michal Entin-Meer , Arnon Afek , Jacob George
DOI: 10.1007/978-1-4419-1599-3_8
关键词:
摘要: Innate immune responses follow accumulation of modified lipids within the arterial wall thereby influencing atherosclerotic plaque progression. One mechanisms evolved in maintaining immunologic self-tolerance involves upregulation regulatory T-cells, among which CD4+CD25+ FoxP3+ T-cells (Treg) are best characterized. The putative important role Treg initiation lesions as well progression towards unstable plaques leading to ischemic events, supported by human studies and, indirectly, murine models. Herein, we summarize experimental approaches taken order study possible involvement atherosclerosis beneficial clinical potential stabilizing plaques.
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R. Kleindienst, Qingbo Xu, G. Wick, S. Weimann, F. R. Waldenberger, J. Willeit, Immunology of atherosclerosis. Demonstration of heat shock protein 60 expression and T lymphocytes bearing alpha/beta or gamma/delta receptor in human atherosclerotic lesions. American Journal of Pathology. ,vol. 142, pp. 1927- 1937 ,(1993)
Afonso R. M. Almeida, Nicolas Legrand, Martine Papiernik, António A. Freitas, Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. Journal of Immunology. ,vol. 169, pp. 4850- 4860 ,(2002) , 10.4049/JIMMUNOL.169.9.4850
Celine S. Lages, Isabelle Suffia, Paula A. Velilla, Bin Huang, Gregg Warshaw, David A. Hildeman, Yasmin Belkaid, Claire Chougnet, Functional Regulatory T Cells Accumulate in Aged Hosts and Promote Chronic Infectious Disease Reactivation Journal of Immunology. ,vol. 181, pp. 1835- 1848 ,(2008) , 10.4049/JIMMUNOL.181.3.1835
Mary E. Brunkow, Eric W. Jeffery, Kathryn A. Hjerrild, Bryan Paeper, Lisa B. Clark, Sue-Ann Yasayko, J. Erby Wilkinson, David Galas, Steven F. Ziegler, Fred Ramsdell, Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nature Genetics. ,vol. 27, pp. 68- 73 ,(2001) , 10.1038/83784
Leonid Gorelik, Richard A. Flavell, Transforming growth factor-β in T-cell biology Nature Reviews Immunology. ,vol. 2, pp. 46- 53 ,(2002) , 10.1038/NRI704
W. Palinski, M. E. Rosenfeld, S. Yla-Herttuala, G. C. Gurtner, S. S. Socher, S. W. Butler, S. Parthasarathy, T. E. Carew, D. Steinberg, J. L. Witztum, Low density lipoprotein undergoes oxidative modification in vivo Proceedings of the National Academy of Sciences of the United States of America. ,vol. 86, pp. 1372- 1376 ,(1989) , 10.1073/PNAS.86.4.1372
Ming O. Li, Shomyseh Sanjabi, Richard A. Flavell, Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms Immunity. ,vol. 25, pp. 455- 471 ,(2006) , 10.1016/J.IMMUNI.2006.07.011
Bernhard Metzler, Manuel Mayr, Hermann Dietrich, Mahauir Singh, Evelyn Wiebe, Qingbo Xu, Georg Wick, Inhibition of Arteriosclerosis by T-Cell Depletion in Normocholesterolemic Rabbits Immunized With Heat Shock Protein 65 Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 19, pp. 1905- 1911 ,(1999) , 10.1161/01.ATV.19.8.1905
Ching-Tai Huang, Creg J. Workman, Dallas Flies, Xiaoyu Pan, Aimee L. Marson, Gang Zhou, Edward L. Hipkiss, Sowmya Ravi, Jeanne Kowalski, Hyam I. Levitsky, Jonathan D. Powell, Drew M. Pardoll, Charles G. Drake, Dario A.A. Vignali, Role of LAG-3 in regulatory T cells. Immunity. ,vol. 21, pp. 503- 513 ,(2004) , 10.1016/J.IMMUNI.2004.08.010
Onno J. de Boer, Jelger J. van der Meer, Peter Teeling, Chris M. van der Loos, Allard C. van der Wal, Low numbers of FOXP3 positive regulatory T cells are present in all developmental stages of human atherosclerotic lesions. PLOS ONE. ,vol. 2, ,(2007) , 10.1371/JOURNAL.PONE.0000779