Transforming growth factor-β in T-cell biology
作者： Leonid Gorelik , Richard A. Flavell
DOI: 10.1038/NRI704
关键词: Cellular differentiation 、 Cell type 、 T cell 、 Cell biology 、 Immune system 、 Biology 、 Transforming growth factor beta 、 Signal transduction 、 Homeostasis 、 In vitro 、 Immunology
摘要: Strict control of T-cell homeostasis is required to permit normal immune responses and prevent undesirable self-targeted responses. Transforming growth factor-beta (TGF-beta) has been shown have an essential role in that regulation. Owing its broad expression, inhibitory effects on multiple cell types the system, TGF-beta regulation complex. Through advances cell-specific targeting signalling vivo, become clearer. Recent vitro studies provide a better understanding how regulates homeostasis, through mechanisms involving numerous types.
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