Perturbations of TGF-β Signaling in Leukocytes as Drivers of Leukemogenesis and Epithelial Tumorigenesis

摘要: The inactivation of specific components the transforming growth factor-beta (TGF-β) signaling pathway has been implicated in many types hematological malignancies. These range from alterations at level TGF-β receptors to mutations, deletions or functional downstream such as members Smad family proteins. It is becoming increasingly apparent that, addition playing a role progression certain leukemias, disruption lymphoid compartment also profound effects on tumor epithelial cells. In this respect, use conditional knockout murine models particularly instructive. We review here well-documented examples where thought control leukemogenesis. More recent data our laboratory and others are lighlighted support for T-cell regulating progression. Finally, we link between TGF-β, regulatory T cells (Treg) immunotherapies, an understanding which significant therapeutic relevance.