Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice.
作者： Masanobu Oshima , Akihiro Matsunaga , Nobuya Sasaki , Makoto M. Taketo , Kazuaki Takaku
DOI:
关键词: Pathology 、 Signet ring cell 、 Knockout mouse 、 Tumor suppressor gene 、 Biology 、 Loss of heterozygosity 、 Stromal cell 、 Juvenile Polyp 、 Adenocarcinoma 、 PTEN
摘要: … The SMAD4 (DPC4) gene … Smad4 and demonstrated its role in the malignant progression of benign adenomas to invasive adenocarcinomas by analyzing mice with Apc and Smad4 …
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