Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period.

摘要: Although many aspects of CD4+CD25+ T regulatory (Treg) cell development remain largely unknown, signaling through the IL-2R represents one feature for production Treg cells. Therefore, present study was undertaken to further define early developmental steps in cells, including a more precise view on role interleukin (IL)-2 this process. After adoptive transfer wild-type cells into neonatal IL-2Rβ−/− mice, only small fraction donor selectively seeded lymph node (LN). These underwent rapid and extensive IL-2–dependent proliferation, followed by subsequent trafficking spleen. Thus, IL-2 is essential proliferation LN. The number distribution periphery normal mice closely paralleled that seen received However, neonates, blockade decreased both thymus two depend upon production, expansion