Impact of Nandrolone Decanoate on Gene Expression in Endocrine Systems Related to the Adverse Effects of Anabolic Androgenic Steroids

摘要: Elite athletes, body builders and adolescents misuse anabolic-androgenic steroids (AAS) in order to increase muscle mass or enhance physical endurance braveness. The high doses misused are associated with numerous adverse effects. purpose of this study was evaluate the impact chronic supratherapeutic AAS treatment on circulating hormones gene expression peripheral tissues related such Quantitative real-time PCR used measure levels total 37 genes (including peptide hormones, cell membrane receptors, nuclear steroid synthesising enzymes other enzymes) pituitary, testes, adrenals, adipose tissue, kidneys liver male Sprague-Dawley rats after 14-day administration nandrolone decanoate, 3 15 mg/kg. Plasma glucose adrenocorticotropic hormone (ACTH), adiponectin, corticosterone, ghrelin, insulin leptin were also measured. We found several expected effects hypothalamic-pituitary-gonadal axis, while caused a number not previously identified changes factors transcription as dose-dependent reduction beta(3)-adrenergic receptor both mRNA up-regulation hydroxymethylglutaryl-CoA-reductase, rate-limiting enzyme de novo synthesis cholesterol, for ACTH adrenals. results provide evidence wide ranging hypothalamic-pituitary-adrenal tissue substrates renal control blood pressure.