Visuocortical function in infants with a history of neonatal jaundice.
作者： Chuan Hou , Anthony M. Norcia , Ashima Madan , William V. Good
关键词: Prospective cohort study 、 Bilirubin 、 Brain damage 、 Postnatal age 、 Evoked potential 、 Physiology 、 Anesthesia 、 Visual acuity 、 Jaundice 、 Medical history 、 Medicine
摘要: Purpose High concentrations of unconjugated bilirubin are neurotoxic and cause brain damage in newborn infants. However, the exact level that may be a given infant is unknown. The aim this study was to use quantitative measure neural activity, swept parameter visual evoked potential (sVEP) determine relationship between neonatal levels responsivity several months later. Methods We compared sVEP response functions over wide range contrast, spatial frequency, Vernier offset sizes 16 full-term infants with high (>10 mg/dL) 18 age-matched no visible jaundice, all enrolled at 14 22 weeks age. group means thresholds suprathreshold amplitudes were compared. correlation individual jaundiced studied. Results Infants who had history jaundice showed lower (P 0.05). Conclusions These results indicate elevated affect measures function infancy up least postnatal
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