AQP5 promotes hepatocellular carcinoma metastasis via NF-κB-regulated epithelial-mesenchymal transition

作者: Zhikuan He , Wenxing Dong , Junhong Hu , Xuequn Ren

DOI: 10.1016/J.BBRC.2017.06.046

关键词: Signal transductionCancer researchCell cultureBiologyMetastasisNF-κBHepatocellular carcinomaVimentinCancerEpithelial–mesenchymal transition

摘要: … Subsequent to blocking with 5% non-fat milk for 1 h at room temperature, the membranes were incubated overnight at 4 C with primary antibodies against AQP5, E-cadherin, α-catenin, …

参考文章(37)
A. S. Verkman, A. N. van Hoek, T. Ma, A. Frigeri, W. R. Skach, A. Mitra, B. K. Tamarappoo, J. Farinas, Water transport across mammalian cell membranes. American Journal of Physiology-cell Physiology. ,vol. 270, ,(1996) , 10.1152/AJPCELL.1996.270.1.C12
Jean Paul Thiery, Hervé Acloque, Ruby Y.J. Huang, M. Angela Nieto, Epithelial-Mesenchymal Transitions in Development and Disease Cell. ,vol. 139, pp. 871- 890 ,(2009) , 10.1016/J.CELL.2009.11.007
Eric McCoy, Harald Sontheimer, Expression and function of water channels (aquaporins) in migrating malignant astrocytes. Glia. ,vol. 55, pp. 1034- 1043 ,(2007) , 10.1002/GLIA.20524
Alexander G. Beristain, Swami R. Narala, Marco A. Di Grappa, Rama Khokha, Homotypic RANK signaling differentially regulates proliferation, motility and cell survival in osteosarcoma and mammary epithelial cells. Journal of Cell Science. ,vol. 125, pp. 943- 955 ,(2012) , 10.1242/JCS.094029
A. S. Verkman, More than just water channels: unexpected cellular roles of aquaporins. Journal of Cell Science. ,vol. 118, pp. 3225- 3232 ,(2005) , 10.1242/JCS.02519
Leilei Chen, Tim Hon Man Chan, Xin-yuan Guan, Chromosome 1q21 amplification and oncogenes in hepatocellular carcinoma Acta Pharmacologica Sinica. ,vol. 31, pp. 1165- 1171 ,(2010) , 10.1038/APS.2010.94
REN FENG SHAN, YUN FEI ZHOU, AI FEN PENG, ZHI GANG JIE, Inhibition of Aurora-B suppresses HepG2 cell invasion and migration via the PI3K/Akt/NF-κB signaling pathway in vitro Experimental and Therapeutic Medicine. ,vol. 8, pp. 1005- 1009 ,(2014) , 10.3892/ETM.2014.1844
Michael Karin, Florian R. Greten, NF-kappaB: linking inflammation and immunity to cancer development and progression. Nature Reviews Immunology. ,vol. 5, pp. 749- 759 ,(2005) , 10.1038/NRI1703
Chengyin Min, Sean F. Eddy, David H. Sherr, Gail E. Sonenshein, NF-κB and epithelial to mesenchymal transition of cancer† Journal of Cellular Biochemistry. ,vol. 104, pp. 733- 744 ,(2008) , 10.1002/JCB.21695