Potential value of localized skin reactions (chancres) induced by Trypanosoma congolense transmitted by Glossina morsitans centralis for the analysis of metacyclic trypanosome populations.

摘要: Summary Goats infected with Trypanosoma congolense transmitted by Glossina morsitans centralis and then treated the trypanocidal drug diminazene aceturate are immune to tsetse-transmitted infection a homologous, but not heterologous trypanosome clone. Immune animals fail develop localized skin reactions (chancres) do become infected, whereas on challenge chancres appear followed parasitaemia. In this study, feasibility of using chancre characterize several different metacyclic populations T. was evaluated. Provided goats were immunized, it found that reaction could be used distinguish congolense. However, problems encountered when attempts made induce immunity against more than one population. When tsetse flies four antigenically unrelated congolense, either simultaneously or at 4 day intervals, adequate immunological priming always achieved. fact, exposed superinfection 8 12 days after primary did an response second (although they organism for infection). Following treatment these subsequently completely susceptible homologous population superinfection, indicating some form interference phenomenon effective level appears prevent delay development following animals.