Impaired cerebellar Purkinje cell potentiation generates unstable spatial map orientation and inaccurate navigation

摘要: Cerebellar activity supported by PKC-dependent long-term depression in Purkinje cells (PCs) is involved the stabilization of self-motion based hippocampal representation, but existence cerebellar processes underlying integration allocentric cues remains unclear. Using mutant-mice lacking PP2B PCs (L7-PP2B mice) we here assess role PP2B-dependent PC potentiation representation and spatial navigation. L7-PP2B mice display higher susceptibility to map instability relative cue impaired as well goal-directed These results indicate that contributes maintain a stable familiar environment an reference frame support optimal trajectory toward goal during