Long-Term Effects of Permanent Vestibular Lesions on Hippocampal Spatial Firing

摘要: The hippocampus is thought to be important for spatial representation processes that depend on the integration of both self-movement and allocentric cues. vestibular system a particularly source information may contribute this representation. To test hypothesis provides hippocampus, rats were given either bilateral labyrinthectomy (n = 6) or sham surgery 6), at least 60 d after hippocampal CA1 neurons recorded extracellularly while animals foraged freely in an open arena. Recorded cells classified as complex spiking 80) noncomplex 33) neurons, their firing fields (place fields) examined. most striking effect lesion was it appeared completely abolish location-related firing. results previous studies provide converging evidence demonstrating processed by hippocampus. disruption input interfere with reconciliation internal signals changes external sensory inputs occur result movement. This would disrupt ability animal integrate egocentric into coherent space.