Calbindin-D28K-containing neurons in animal models of neurodegeneration: possible protection from excitotoxicity
作者： A. Iacopino , S. Christakos , D. German , P.K. Sonsalla , C.A. Altar
DOI: 10.1016/0169-328X(92)90033-8
关键词: Quinolinic acid 、 Endocrinology 、 Neuroprotection 、 MPTP 、 Neurodegeneration 、 Neurotoxin 、 Substantia nigra 、 Neuroscience 、 Biology 、 Internal medicine 、 Dopaminergic 、 Neurotoxicity
摘要: Brain levels of the calcium binding protein Calbindin-D28K (CaBP28K) and CaBP28K mRNA were measured for various animal models neurodegenerative diseases (MPTP-treated C57BL/6J mice Sprague-Dawley rats receiving striatal/intraperitoneal kainic acid or quinolinic into nucleus basalis magnocellularis). areas tested (radioimmunoassay, Western blot, slot Northern blot) mRNA. The did not exhibit any changes in from controls, suggesting that CaBP28K-containing neurons lost after exposure to these neurotoxins. Immunocytochemical characterization substantia nigra MPTP-treated revealed there was significant dopaminergic cell loss this brain area MPTP treatment. majority degenerated contain CaBP28K. small percentage surviving CaBP28K-positive. These results suggest presence may protect calcium-mediated neurotoxicity.
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