Kinetics of cisplatin in an anuric patient undergoing hemofiltration dialysis.

摘要: After in vitro tests, a tracer dose of cisplatin was administered to an anuric cancer patient. Plasma total platinum levels were monitored as function time, filterable elimination by hemofiltration dialysis. Based on the derived pharmacokinetic parameters, patient later given 50-mg doses cisplatin, once single agent, then four times combination with doxorubicin, VM-26, and cyclophosphamide. could be fitted sum three exponentials after infusion stopped. The mean corresponding half-lives are 30 minutes, 6 hours, 5 days. Depending rate infusion, plasma peaks ranged between 1.1 micrograms/ml (5.7 X 10(-6) M) 2.27 (1.16 10(-5) M). During process immediately following first-order, half-life 60 minutes. amount eliminated during first session 8% dose, decreasing about 3% Days 2 3. A partial tumor response observed two treatment courses, evidenced relief abdominal pain bowel obstruction episodes 50% decrease peritoneal metastases.