Cytotoxic effects of long-term circulating ultrafiltrable platinum species and limited efficacy of haemodialysis in clearing them

摘要: We applied haemodialysis to clear platinum (Pt) circulating species following renal insufficiency due an accidental cisplatin overdosage (205 mg/m2 instead of 100 mg/m2). Serum samples were repeatedly obtained during this clinical episode from day 5 up 30 after dosing. A serum aliquot taken at 22 administration was tested assess the possible cytotoxicity exhibited by Pt on a head and neck tumour cell line. The profile ultrafiltrable (UF) successive cycles striking. After each cycle, marked decrease in UF Pt, occurred but followed more or less pronounced rebounds. Cisplatin concentration-cytotoxic effect curves vitro patient before healthy control very similar concentration profiles. In contrast, resulted cytotoxic effects, which much greater than those could have been anticipated considering sample. present report underlines limited usefulness for rescuing treated patients, exhibiting unanticipated postinfusion failure with overexposure drug. investigations suggest that pharmacological effects derivatives may not only be attributable short-term drug diffusion into tissues, also delayed species.