Rhodium-catalyzed [2+2+2] cycloaddition of various fluorine-containing alkynes—novel synthesis of multi-substituted fluoroalkylated aromatic compounds
作者： Tsutomu Konno , Kazuki Moriyasu , Ryoko Kinugawa , Takashi Ishihara
DOI: 10.1039/B926192C
关键词: Ether 、 Medicinal chemistry 、 Cycloaddition 、 Rhodium 、 Chemistry 、 Molecule 、 Toluene 、 Fluorine containing 、 Organic chemistry 、 Catalysis 、 Bicyclic molecule
摘要: Treatment of various fluorinated internal alkynes with 10 mol% RhCl3·H2O and 30 i-Pr2NEt in toluene at the reflux temperature for 18 h gave corresponding trimerization products as an isomeric mixture high yields. Cycloaddition using 1.0 equiv. 2.0 non-fluorinated under same reaction conditions led to mono- bis-fluoroalkylated benzene derivatives yields, together small amounts products. The fluorine-containing bispropargyl ether took place smoothly afford bicyclic molecules good
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