Prognostic implications of heart failure with preserved ejection fraction in patients with an exacerbation of chronic obstructive pulmonary disease

摘要: Diagnosing heart failure with preserved ejection fraction (HFpEF) in patients chronic obstructive pulmonary disease (COPD) is difficult due to overlapping pathophysiological pathways, risk factors and clinical presentations. We investigated the prevalence prognostic implications of coexisting HFpEF hospitalized for acute exacerbation COPD. A total 116 consecutive an COPD were evaluated followed average period 22 ± 9 months occurrence death from any cause. was diagnosed 22 (19 %) COPD, who older, also had higher LV mass, left atrial size, mitral E/Ea ratio than those without (p < 0.05 all comparisons). not independently associated all-cause mortality [hazard (HR) 1.07, 95 % confidence interval (CI) 0.44-2.62]. Global initiative Obstructive Lung Disease (GOLD) stage (IV vs. I-III, HR 2.37, CI 1.23-4.59) N-terminal pro B-type natriuretic peptide (NT-proBNP) levels (HR 2.79, 1.12-6.98) independent predictors long-term survival. present one-fifth exacerbated Non-invasively may be predictor mortality. Elevated NT-proBNP very severe unfavorable overall