Biomarkers Predictive of Exacerbations in the SPIROMICS and COPDGene Cohorts
作者： Jason D. Keene , Sean Jacobson , Katerina Kechris , Gregory L. Kinney , Marilyn G. Foreman
DOI: 10.1164/RCCM.201607-1330OC
关键词:
摘要: Rationale: Chronic obstructive pulmonary disease exacerbations are associated with progression, higher healthcare cost, and increased mortality. Published predictors of future include previous exacerbation, airflow obstruction, poor overall health, home oxygen use, gastroesophageal reflux.Objectives: To determine the value adding blood biomarkers to clinical variables predict exacerbations.Methods: Subjects from SPIROMICS (Subpopulations Intermediate Outcomes Measures in COPD Study) (n = 1,544) COPDGene (Genetic Epidemiology COPD) (n = 602) cohorts had 90 plasma or serum candidate proteins measured on study entry using Myriad-RBM multiplex panels. We defined total as subject-reported worsening respiratory health requiring therapy corticosteroids and/or antibiotics, severe those leading hospitalizations emergency room visits. assessed retrospective during 12 months before enrollment then...
elsevier.com
sci-hub.se 参考文章(40)
Achim Zeileis, Christian Kleiber, Simon Jackman, Regression Models for Count Data in R Journal of Statistical Software. ,vol. 27, pp. 1- 25 ,(2008) , 10.18637/JSS.V027.I08
Pere Almagro, Carmen Hernandez, Pablo Martinez-Camblor, Ricard Tresserras, Joan Escarrabill, Seasonality, ambient temperatures and hospitalizations for acute exacerbation of COPD: a population-based study in a metropolitan area International Journal of Chronic Obstructive Pulmonary Disease. ,vol. 10, pp. 899- 908 ,(2015) , 10.2147/COPD.S75710
Sanjay Sethi, Timothy F. Murphy, Infection in the Pathogenesis and Course of Chronic Obstructive Pulmonary Disease The New England Journal of Medicine. ,vol. 359, pp. 2355- 2365 ,(2008) , 10.1056/NEJMRA0800353
P. K. Andersen, R. D. Gill, Cox's Regression Model for Counting Processes: A Large Sample Study Annals of Statistics. ,vol. 10, pp. 1100- 1120 ,(1982) , 10.1214/AOS/1176345976
Steven Pascoe, Nicholas Locantore, Mark T Dransfield, Neil C Barnes, Ian D Pavord, Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trials The Lancet Respiratory Medicine. ,vol. 3, pp. 435- 442 ,(2015) , 10.1016/S2213-2600(15)00106-X
John R. Hurst, Jørgen Vestbo, Antonio Anzueto, Nicholas Locantore, Hana Müllerova, Ruth Tal-Singer, Bruce Miller, David A. Lomas, Alvar Agusti, William MacNee, Peter Calverley, Stephen Rennard, Emiel F.M. Wouters, Jadwiga A. Wedzicha, Susceptibility to Exacerbation in Chronic Obstructive Pulmonary Disease The New England Journal of Medicine. ,vol. 363, pp. 1128- 1138 ,(2010) , 10.1056/NEJMOA0909883
John G. Cragg, Russell S. Uhler, The Demand for Automobiles Canadian Journal of Economics. ,vol. 3, pp. 386- 406 ,(1970) , 10.2307/133656
Ching-Min Tseng, Yung-Tai Chen, Shuo-Ming Ou, Yi-Han Hsiao, Szu-Yuan Li, Shuu-Jiun Wang, Albert C. Yang, Tzeng-Ji Chen, Diahn-Warng Perng, The Effect of Cold Temperature on Increased Exacerbation of Chronic Obstructive Pulmonary Disease: A Nationwide Study PLoS ONE. ,vol. 8, pp. e57066- ,(2013) , 10.1371/JOURNAL.PONE.0057066
Russell P Bowler, Victor Kim, Elizabeth Regan, André AA Williams, Stephanie A Santorico, Barry J Make, David A Lynch, John E Hokanson, George R Washko, Peter Bercz, Xavier Soler, Nathaniel Marchetti, Gerard J Criner, Joe Ramsdell, MeiLan K Han, Dawn Demeo, Antonio Anzueto, Alejandro Comellas, James D Crapo, Mark Dransfield, J Michael Wells, Craig P Hersh, Neil MacIntyre, Fernando Martinez, Hrudaya P Nath, Dennis Niewoehner, Frank Sciurba, Amir Sharafkhaneh, Edwin K Silverman, Edwin JR van Beek, Carla Wilson, Christine Wendt, Robert A Wise, Jeffrey Curtis, Ella Kazerooni, Nicola Hanania, Philip Alapat, Venkata Bandi, Kalpalatha Guntupalli, Elizabeth Guy, William Lunn, Antara Mallampalli, Charles Trinh, Mustafa Atik, Dawn DeMeo, Craig Hersh, Francine Jacobson, R Graham Barr, Byron Thomashow, John Austin, Lacey Washington, H Page McAdams, Richard Rosiello, Timothy Bresnahan, Charlene McEvoy, Joseph Tashjian, Robert Wise, Nadia Hansel, Robert Brown, Richard Casaburi, Janos Porszasz, Hans Fischer, Matt Budoff, Tadashi Allen, Kathryn Rice, Marilyn Foreman, Gloria Westney, Eugene Berkowitz, Russell Bowler, Adam Friedlander, Eleonora Meoni, Gerard Criner, Aditi Satti, A James Mamary, Robert Steiner, Chandra Dass, William Bailey, Lynn Gerald, Hrudaya Nath, Paul Ferguson, Paul Friedman, Geoffrey McLennan, MeiLan Han, Deborah Thompson, Joel Weissfeld, Carl Fuhrman, Jessica Bon, Sandra Adams, Carlos Orozco, C Santiago Restrepo, Amy Mumbower, James Crapo, Edwin Silverman, Barry Make, Jonathan Samet, Amy Willis, Douglas Stinson, Terri Beaty, Barbara Klanderman, Nan Laird, Christoph Lange, Iuliana Ionita, Stephanie Santorico, David Lynch, Joyce Schroeder, John Newell, John Reilly, Harvey Coxson, Philip Judy, Eric Hoffman, Raul San Jose Estepar, George Washko, Rebecca Leek, Jordan Zach, Alex Kluiber, Anastasia Rodionova, Tanya Mann, Robert Crapo, Robert Jensen, Homayoon Farzadegan, James Murphy, Douglas Everett, John Hokanson, Prediction of acute respiratory disease in current and former smokers with and without COPD Chest. ,vol. 146, pp. 941- 950 ,(2014) , 10.1378/CHEST.13-2946
Mette Thomsen, Truls Sylvan Ingebrigtsen, Jacob Louis Marott, Morten Dahl, Peter Lange, Jørgen Vestbo, Børge G. Nordestgaard, Inflammatory biomarkers and exacerbations in chronic obstructive pulmonary disease JAMA. ,vol. 309, pp. 2353- 2361 ,(2013) , 10.1001/JAMA.2013.5732