The use of cellular and molecular biomarkers to manage COPD exacerbations

摘要: Chronic obstructive pulmonary disease (COPD) exacerbations are a common cause of respiratory morbidity and mortality, have various etiologies. Multiple cellular molecular biomarkers been associated with exacerbations. Quantitative sputum cell counts able to identify the presence type bronchitis, which is an important contributor Their utility monitor bronchitis help treat has evaluated, yet they not used in routine clinical practice. Areas covered: This review will provide brief summary utilized COPD, focus on application markers for management A case study demonstrate these methods. With quantitative counts, eosinophilic predicts corticosteroid-responsiveness, while neutrophilic identifies infection suggests need antibiotics. Gastroesophageal reflux-related aspiration heart failure can also be identified by examining sputum. Expert commentary: cytometry essential tool particularly those prone frequent Treatment based superior current guideline-based recommendations prevent future hospitalizations observational single-centre controlled trials. Large multicentre trials necessary confirm this.