PH-responsive hydrogels with dispersed hydrophobic nanoparticles for the oral delivery of chemotherapeutics
作者： Cody A. Schoener , Heather N. Hutson , Nicholas A. Peppas
DOI: 10.1002/JBM.A.34532
关键词: Doxorubicin 、 Small intestine 、 Amphiphilic copolymer 、 Polymerization 、 Polymer 、 Controlled release 、 Chemical engineering 、 Polymer chemistry 、 Materials science 、 Nanoparticle 、 Self-healing hydrogels
摘要: Amphiphilic polymer carriers were formed by polymerizing a hydrophilic, pH-responsive hydrogel composed of poly(methacrylic-grafted-ethylene glycol) (P(MAA-g-EG)) in the presence hydrophobic PMMA nanoparticles. These varied nanoparticle content to elicit variety physiochemical properties which would preferentially load doxorubicin, chemotherapeutic, and release doxorubicin locally colon for treatment cancers. Loading levels ranged from 49% 64% increased with increasing content. Doxorubicin loaded polymers released physiological model where low pH was used simulate stomach then stepped more neutral conditions upper small intestine. P(MAA-g-EG) containing nanoparticles less mucoadhesive as determined using tensile tester, samples, fresh porcine The cytocompatibility materials assessed cell lines representing GI tract cancer noncytotoxic at varying concentrations exposure times.
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