Alteration of Na+ currents in dorsal root ganglion neurons from rats with a painful neuropathy.

摘要: Abstract Increased excitability of primary sensory neurons may be important for the generation neuropathic pain from nerve injury. The currents underlying action potentials these are largely carried by Na + , and changes in have been postulated to contribute this increased excitability. Using patch clamp whole-cell mode, we recorded DRG freshly isolated rats with a chronic constriction injury (CCI), an animal model pain. We found significant after CCI when cell size channel properties were used segregate neurons. Most concentrated small (≤25 μ m diameter) slow, TTX-resistant current that is predominant cells. produced two principle cells: it shifted voltage-dependence activation more negative potentials, reduced average density current. decrease appears primarily due number expressing net result change both steady-state inactivation total without similar those some hyperalgesic autacoids, increase afferent hyperalgesia occurs lesion.