Relationship between swallow rate and salivary flow

摘要: Recent studies indicate that swallow-induced, primary peristalsis is a major determinant of normal esophageal acid clearance. However, factors regulate the rate spontaneous swallowing in subjects are incompletely understood. We postulated salivary flow influences swallows. To test this hypothesis, we did total 60 measuring or 10 healthy volunteers, age 10–30 years. Saliva was collected by expectoration. Swallow recorded small, transnasal catheter stationed pharynx and also, some circumstances, cervical electrodes. On separate sessions, evaluated effect five manipulations on rate, respectively. The consisted of: (1) pharyngeal intubation, (2) sucking dummy lozenge, (3) peppermint (4) bethanechol injection (5 mg subcutaneously), atropine administration (12 μg/kg intravenously). Pharyngeal intubation caused but significant increase salivation Sucking lozenge sixfold while nearly doubling whereas only modest swallowing. Cholinergic stimulation elicited substantial rate. In contrast, decrease both conclude awake, swallows influenced directly flow. Because oral lozenges substantially flow, such agents merit investigation as potentially useful ancillary treatment for relief heartburn.