Stéato-hépatite, surcharge en fer et insulinorésistance
作者： Y. Deugnier , F. Lainé , C. Jézéquel , F. Bonnet
DOI: 10.1016/S1957-2557(12)70377-2
关键词: Gynecology 、 Medicine
摘要: L’insulinoresistance est associee de facon etroite a la steatopathie metabolique et des perturbations du metabolisme fer type d’hyperferritinemie ou d’hepatosiderose dysmetabolique. La devenue maladie hepatique plus frequente dans les pays developpes ; elle confere un sur-risque vital aux patients qui en sont atteints (cirrhose, carcinome hepatocellulaire accroissement risque vasculaire). L’hepatosiderose dysmetabolique pourrait aggraver, voire declencher, l’insulinoresistance et, steatopathie, augmenterait le d’evolution fibrogene. Pour ces raisons, l’impact hepatologique syndrome merite d’etre connu, repere (recherche d’une cytolyse hyperferritinemie, echographie…) specifiquement pris charge au plan surveillance (bilan regulier, echographie semestrielle cas fibrose evoluee…).
em-consulte.com参考文章(25)
E. Bardou-Jacquet, P. Brissot, Y. Deugnier, C. Le Lan, Hyperferritinémies non hémochromatosiques Gastroenterologie Clinique Et Biologique. ,vol. 33, pp. 323- 326 ,(2009) , 10.1016/J.GCB.2009.02.009
Naoki Fujita, Yoshiyuki Takei, Iron overload in nonalcoholic steatohepatitis. Advances in Clinical Chemistry. ,vol. 55, pp. 105- 132 ,(2011) , 10.1016/B978-0-12-387042-1.00006-X
Marc Ruivard, Fabrice Lainé, Tomas Ganz, Gordana Olbina, Mark Westerman, Elizabeta Nemeth, Mathieu Rambeau, André Mazur, Laurent Gerbaud, Valérie Tournilhac, Armand Abergel, Pierre Philippe, Yves Deugnier, Charles Coudray, Iron absorption in dysmetabolic iron overload syndrome is decreased and correlates with increased plasma hepcidin. Journal of Hepatology. ,vol. 50, pp. 1219- 1225 ,(2009) , 10.1016/J.JHEP.2009.01.029
Yves Deugnier, Pierre Brissot, Olivier Loréal, Iron and the liver: update 2008. Journal of Hepatology. ,vol. 48, ,(2008) , 10.1016/J.JHEP.2008.01.014
M. Luque-Ramirez, F. Alvarez-Blasco, J. I. Botella-Carretero, R. Sanchon, J. L. San Millan, H. F. Escobar-Morreale, Increased Body Iron Stores of Obese Women With Polycystic Ovary Syndrome Are a Consequence of Insulin Resistance and Hyperinsulinism and Are Not a Result of Reduced Menstrual Losses Diabetes Care. ,vol. 30, pp. 2309- 2313 ,(2007) , 10.2337/DC07-0642
D LAPENNA, S PIERDOMENICO, G CIOFANI, S UCCHINO, M NERI, M GIAMBERARDINO, F CUCCURULLO, Association of body iron stores with low molecular weight iron and oxidant damage of human atherosclerotic plaques. Free Radical Biology and Medicine. ,vol. 42, pp. 492- 498 ,(2007) , 10.1016/J.FREERADBIOMED.2006.11.014
Stefano Romeo, Isabel Huang-Doran, Marco Giorgio Baroni, Anna Kotronen, Unravelling the pathogenesis of fatty liver disease: patatin-like phospholipase domain-containing 3 protein. Current Opinion in Lipidology. ,vol. 21, pp. 247- 252 ,(2010) , 10.1097/MOL.0B013E328338CA61
Jerome l. Sullivan, Macrophage iron, hepcidin, and atherosclerotic plaque stability. Experimental Biology and Medicine. ,vol. 232, pp. 1014- 1020 ,(2007) , 10.3181/0703-MR-54
Pierre Brissot, Edouard Bardou-Jacquet, Anne-Marie Jouanolle, Olivier Loréal, Iron disorders of genetic origin: a changing world Trends in Molecular Medicine. ,vol. 17, pp. 707- 713 ,(2011) , 10.1016/J.MOLMED.2011.07.004
Curtis K. Argo, Stephen H. Caldwell, Epidemiology and Natural History of Non-Alcoholic Steatohepatitis Clinics in Liver Disease. ,vol. 13, pp. 511- 531 ,(2009) , 10.1016/J.CLD.2009.07.005