Increased Body Iron Stores of Obese Women With Polycystic Ovary Syndrome Are a Consequence of Insulin Resistance and Hyperinsulinism and Are Not a Result of Reduced Menstrual Losses

摘要: OBJECTIVE —Increased serum ferritin levels, indicating increased body iron stores, have been found in overweight and obese women with polycystic ovary syndrome (PCOS). This finding might result from reduced menstrual losses secondary to oligo- or amenorrhea hyperinsulinism insulin resistance, because favors the intestinal absorption tissue deposition of iron. To explore which these mechanisms is responsible for increase stores PCOS, we monitored changes levels during treatment an antiandrogenic oral contraceptive sensitizer. RESEARCH DESIGN AND METHODS —Thirty-four consecutive PCOS patients were randomized containing 35 μg ethinyl-estradiol plus 2 mg cyproterone acetate (Diane Diario) metformin (850 twice daily), their evaluated at baseline after 12 24 weeks treatment. RESULTS —Despite fact that Diane Diario restored regular cycles all patients, whereas only did so 50% them, decreased metformin, association a marked sensitivity. On contrary, no sensitivity observed Diario. CONCLUSIONS —Our present results suggest resistance hyperinsulinism, not amenorrhea, are PCOS.