Inadequate hepcidin serum concentrations predict incident type 2 diabetes mellitus.

摘要: Background Type 2 diabetes mellitus (T2DM) is closely associated with elevated body iron stores. The hormone hepcidin the key regulator of homeostasis. Inadequately low levels were recently reported in subjects manifest T2DM. We investigated whether alterations precede manifestation T2DM and predict development independently established risk conditions. Methods This prospective population-based study included 675 aged 50–89 years, 51.9% whom female. Hepcidin measured by gold standard tandem mass spectrometry. Diabetes was diagnosed according to American Association criteria, incident recorded between baseline 2000 2010. Results The hepcidin-to-ferritin ratio that subsequently developed during follow-up reduced on average 29.8% as compared normal glucose tolerance (95% confidence interval, −50.7% −0.2%; p = 0.049). After adjustment for age, sex, serum ferritin, higher (hazard per 1-unit log2 hepcidin, 0.80; 95% 0.64–0.98; p = 0.035; 33 events). Additional factors determinants concentration did not appreciably change these results (HR, 0.81; CI, 0.66–0.99). Likewise, inadequately also detected prevalent (n = 76). Conclusions Hepcidin are relation stores an independent predictor may contribute diabetes-related tissue overload. Copyright © 2015 John Wiley & Sons, Ltd.