Comparative protein structure modeling of genes and genomes

摘要: ■ Abstract Comparative modeling predicts the three-dimensional structure of a given protein sequence (target) based primarily on its alignment to one or more pro- teins known (templates). The prediction process consists fold assign- ment, target-template alignment, model building, and evaluation. number sequences that can be modeled accuracy predictions are in- creasing steadily because growth in structures improvements software. Further advances nec- essary recognizing weak sequence-structure similarities, aligning with structures, rigid body shifts, distortions, loops side chains, as well detecting errors model. Despite these problems, it is currently possible useful significant parts approximately third all sequences. use individual comparative models biology already rewarding increasingly widespread. A major new challenge for integration torrents data from genome sequencing projects functional structural genomics. In particular, there need develop an automated, rapid, robust, sensitive, accurate pipeline applicable whole genomes. Such large-scale likely encourage kinds applications many resulting models, their large completeness at level family, organism, network.