Structural Characterization of Mucin O-Glycosylation May Provide Important Information to Help Prevent Colorectal Tumor Recurrence.

摘要: Although colorectal cancer is a preventable and curable disease if early stage tumors are removed, it still represents the second cause of cancer-related death worldwide. Surgical resection only curative treatment but once operated patient either subjected to adjuvant chemotherapy or not, depending on invasiveness risks recurrence. In this context, we investigated, by mass spectrometry (MS), alterations in repertoire glycosylation mucins from various stages, grades, recurrence status. Tumors were also compared with their counterparts margins same patients healthy controls. The obtained data showed an important decrease level expression sialylated core 3-based O-glycans correlated increase 1 structures. No correlation was established between stages tumor samples mucin O-glycosylation. However, notable exception sialyl Tn antigens, presented milder alteration profile than without These results suggest that might mimic healthier physiological situation, hence deceiving immune defense system.