Multiple system atrophy: genetic or epigenetic?

摘要: Multiple system atrophy (MSA) is a rare, late-onset and fatal neurodegenerative disease including multisystem neurodegeneration the formation of α-synuclein containing oligodendroglial cytoplasmic inclusions (GCIs), which present hallmark disease. MSA considered to be sporadic disease; however certain genetic aspects have been studied during last years in order shed light on largely unknown etiology pathogenesis Epidemiological studies focused possible impact environmental factors development. This article gives an overview findings from epigenetic discusses role or pathogenesis.