Support for association between ADHD and two candidate genes: NET1 and DRD1
作者： Aaron J. Bobb , Anjene M. Addington , Ellen Sidransky , Michele C. Gornick , Jason P. Lerch
DOI: 10.1002/AJMG.B.30142
关键词: Transmission disequilibrium test 、 Attention deficit hyperactivity disorder 、 Single-nucleotide polymorphism 、 Linkage disequilibrium 、 Medicine 、 Norepinephrine transporter 、 Candidate gene 、 Atomoxetine 、 Genetic determinism 、 Genetics
摘要: Attention deficit hyperactivity disorder (ADHD) is a common, multifactorial with significant genetic contribution. Multiple candidate genes have been studied in ADHD, including the norepinephrine transporter (NET1) and dopamine D1 receptor (DRD1). NET1 implicated ADHD because of efficacy atomoxetine, selective noradrenergic reuptake inhibitor, treatment ADHD. DRD1 primarily through mouse models DNA from 163 probands, 192 parents, 129 healthy controls was used to investigate possible associations between polymorphisms 12 previously (5-HT1B, 5-HT2A, 5-HT2C, ADRA2A, CHRNA4, COMT, DAT1, DRD1, DRD4, DRD5, NET1, SNAP-25). Analyses included case-control family-based methods, dimensional measures behavior, cognition, anatomic brain magnetic resonance imaging (MRI). Of examined, two showed association Transmission disequilibrium test (TDT) analysis revealed single nucleotide (SNPs) (P < or = 0.009); SNPs 0.008). No behavioral, cognitive, MRI volume measurement significantly differed across genotypes at an alpha 0.01. This study provides support for both DRD1; ten other were not associated Because methods gave divergent results, should be studies
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