Immunobarriers of the Mucosa of the Upper Respiratory and Digestive Pathways
作者： P. Brandtzaeg
DOI: 10.3109/00016488809119462
关键词: Lymph 、 Immune system 、 Lymphatic system 、 Biology 、 Serous fluid 、 Secretory component 、 Immunology 、 Selective IgA deficiency 、 Molecular biology 、 Respiratory system 、 Antibody
摘要: The mucosa that lines the upper respiratory and digestive pathways is protected by a secretory immune system which under complex only partly understood immuno-regulatory control. B cells of relatively immature memory clones with potential for J-chain expression, are initially stimulated in mucosa-associated lymphoid tissue (probably including tonsils) migrate thereafter through lymph blood to glandular sites where they subjected terminal differentiation become immunoglobulin (Ig)-producing immunocytes. Most locally produced Ig normally dimeric IgA selectively transported serous type means an epithelial receptor protein called component (SC). IgM also SC-mediated transport. In patients selective deficiency, lacking, but may be satisfactorily replaced protective IgM. other IgA-deficient patients, however, immunoregulatory compensation gives rise large ...
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