Sphingolipid derivatives and their methods of use

摘要: Derivatives of sphingolipids formula (I) are provided wherein the substituents as defined in specification and there is at least one R2 substituent sphingolipid derivative. The compounds useful treatment abnormal cell proliferation, including benign malignant tumors, promotion differentiation, induction apoptosis, inhibition protein kinase C, inflammatory conditions, psoriasis, bowel disease well proliferation smooth muscle cells course development plaques vascular tissue. invention also includes a method for triggering release cytochrome c from mitochondria that administering an effective amount or its derivative prodrug to host need thereof. Further, provides treating bacterial infections, those influence colon cancer other disorders intestine, active identified herein.