Use of sphingolipids in the treatment of type 2 diabetes mellitus, insulin resistance and metabolic syndrome
作者： Aloysius Maria Havekes , Josephus Jan Emeis , Willem Ferdinand Nieuwenhuizen
DOI:
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摘要: The present invention relates to the use of sphingolipids for preparation a food item, supplement and/or medicament treatment insulin resistance, diabetes mellitus type 2 metabolic syndrome. In particular, sphingolipid with general formula (I): wherein Z is R3 or —CH(OH)—R3; A sulphate, sulphonate, phosphate, phosphonate —C(O)O—; R1 H, hydroxyl, alditol, aldose, an alcohol, C1-C6 alkyl amino acid; R2 H unsaturated saturated (C1-C30) chain; Q1 primary amine group (—NH2), secondary (—NH—) amide (—NH—CO—); and t 0 1, precursor, derivative pharmaceutically acceptable salt thereof, manufacture prevention disorder selected from consisting
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