Liposomal compositions, and methods of using liposomal compositions to treat dislipidemias

作者: Kevin Jon Williams , Michael J. Hope , Wendi V. Rodrigueza

DOI:

关键词:

摘要: The present invention provides a liposomal composition for treating dislipidemias in human subjects, method of using composition, and devices modes operation the compositions, kits related thereto. reverse transport cholesterol from peripheral tissues to liver warm blood mammal while controlling plasma atherogenic lipoprotein concentrations, including LDL concentrations. A described above mode includes stop administering an effective amount multiplicity acceptors comprised phospholipids substantially free sterol. optionally periodically assaying concentrations with assay during treatment period assess obtain profile.

参考文章(153)
Gregory Gregoriadis, Judith Senior, Liposomes In Vivo: A Relationship between Stability and Clearance? Springer, Boston, MA. pp. 183- 192 ,(1986) , 10.1007/978-1-4684-5185-6_13
P. Dewailly, E. Decoopman, C. Desreumaux, J. C. Fruchart, Plasma Removal of Intravenous Essential Phospholipids in Man Springer, Berlin, Heidelberg. pp. 80- 86 ,(1976) , 10.1007/978-3-642-66424-3_6
Verne N. Schumaker, Donald L. Puppione, Sequential flotation ultracentrifugation. Methods in Enzymology. ,vol. 128, pp. 155- 170 ,(1986) , 10.1016/0076-6879(86)28066-0
K J Williams, R W Brocia, E A Fisher, The unstirred water layer as a site of control of apolipoprotein B secretion. Journal of Biological Chemistry. ,vol. 265, pp. 16741- 16744 ,(1990) , 10.1016/S0021-9258(17)44822-8
Peter M. Howley, Mark A. Israel, Joe W. Gray, Craig B. Thompson, John Mendelsohn, The Molecular Basis of Cancer ,(1985)
Yechezkel Barenholz, Elishalom Yechiel, Lipid replacement therapy ,(1986)
Pieter R. Cullis, Lawrence D. Mayer, Nancy L. Boman, Marcel B. Bally, Liposomal compositions for enhanced retention of bioactive agents ,(1993)
A. Miyazaki, M. Sakai, Y. Suginohara, H. Hakamata, Y. Sakamoto, W. Morikawa, S. Horiuchi, Acetylated low density lipoprotein reduces its ligand activity for the scavenger receptor after interaction with reconstituted high density lipoprotein. Journal of Biological Chemistry. ,vol. 269, pp. 5264- 5269 ,(1994) , 10.1016/S0021-9258(17)37683-4