Iridium(iii)-catalyzed regioselective direct arylation of sp(2) C-H bonds with diaryliodonium salts.
作者： Pan Gao , Li Liu , Zhuangzhi Shi , Yu Yuan
DOI: 10.1039/C6OB01145D
关键词: Medicinal chemistry 、 Metal 、 Chemistry 、 Halide 、 Catalysis 、 Reagent 、 Cationic polymerization 、 Iridium 、 Organic chemistry 、 Regioselectivity 、 Reaction conditions
摘要: A regioselective direct arylation of arenes and olefins at the ortho position is reported. The key to high selectivity appropriate choice diaryliodonium salts as arylating reagent in presence a cationic iridium(iii) catalyst. coordination metal with an oxygen atom or nitrogen subsequent C-H activation allows for coupling partners. This reaction proceeds under mild conditions tolerance various functional groups including many halide groups.
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