Chondroitin sulfate and sulfated hyaluronan-containing collagen coatings of titanium implants influence peri-implant bone formation in a minipig model

作者: P. Korn , M. C. Schulz , V. Hintze , U. Range , R. Mai

DOI: 10.1002/JBM.A.34913

关键词: OsseointegrationChondroitin sulfateDental implantOsteoidDentistryIn vivoExtracellular matrixMaterials scienceTitaniumImplant

摘要: An improved osseous integration of dental implants in patients with lower bone quality is particular interest. The aim this study was to evaluate the effect artificial extracellular matrix implant coatings on early formation. contained collagen (coll) conjunction either chondroitin sulfate (CS) or sulfated hyaluronan (sHya). Thirty-six screw-type, grit-blasted, and acid-etched titanium were inserted mandible 6 minipigs. Three surface states tested: (1) uncoated control (2) coll/CS (3) coll/sHya. After healing periods 4 8 weeks, contact (BIC), volume density (BVD) as well osteoid related parameters measured. showed a BIC 44% which comparable coated (48%) significantly higher compared coll/sHya (37%, p = 0.012). This difference leveled out after weeks. No significant differences could be detected for BVD values weeks all surfaces reduced However, at that time, around both, (30%, p = 0.029), (32%, p = 0.015), controls (22%). (OIC) no OIC coll/CS, latter being (0.9% vs. 0.4%, There density. In summary, by chosen organic components certain potential influence osseointegration vivo. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.

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