Biodegradable poly(DL-lactic-co-glycolic acid) microspheres containing tetracaine hydrochloride. In-vitro release profile.
作者： L. RAMIREZ
关键词: Solvent 、 PLGA 、 Materials science 、 Emulsion 、 Pulmonary surfactant 、 Stereochemistry 、 Chromatography 、 Glycolic acid 、 Tetracaine 、 Drug carrier 、 Dosage form
摘要: Tetracaine does not result in effective treatment of intractable pain caused by trigeminal neuralgiabecause its short duration effect. In asustained release system a controlled delivery the drug at site administration, would avoid successive administrations. hydrochloride (HCl) has been encapsulated using technique based on evaporation solvent from an O/O emulsion, poly(dl-lactic-co-glycolic acid) (PLGA) 50:50. Microspheres were separated into three fractions: 106-212, 212-300 and 300-425mum. The effects two variables manufacturing method (volume inner phase emulsion volume surfactant added to external phase) loading microspheres, dissolution profiles SEM characterization microspheres evaluated. containing tetracaine (up to94% referred tothe theoretical) released drug, in-vitro, over 35 days. HCl was delivered according zero order kinetics day 5 un...
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