High dietary menaquinone intake is associated with reduced coronary calcification

摘要: Abstract Background Dietary vitamin K is thought to decrease risk of cardiovascular disease by reducing coronary calcification, but inconsistent results are reported. This may be due different effects 1 (phylloquinone) and 2 (menaquinone, MK), few studies included both. Methods We investigated the association intake phylloquinone menaquinone, including its subtypes (MK4–MK10), with calcification in a cross-sectional study among 564 post-menopausal women. Phylloquinone menaquinone was estimated using food-frequency questionnaire. Results Sixty-two percent ( n =360) women had based on 1.5-mm thick slices. not associated relative (RR) 1.17 (95%-confidence interval: 0.96–1.42; p trend =0.11) highest versus lowest quartile. Menaquinone decreased an RR 0.80 (95%-CI: 0.65–0.98; =0.03). Conclusion shows that high dietary intake, probably phylloquinone, reduced calcification. Adequate intakes could therefore important prevent disease.