The role of eicosanoids in tumor growth and metastasis.
作者： D. Nie , K. Tang , K. Szekeres , M. Trikha , K. V. Honn
DOI: 10.1007/978-3-662-04047-8_10
关键词: Protein kinase C 、 Lipoxygenase 、 Kinase 、 Chemistry 、 Cell biology 、 Epoxygenase 、 Arachidonic acid 、 Signal transduction 、 Cyclic adenosine monophosphate 、 Growth factor
摘要: Mobilization of esterified arachidonic acid (AA) from membrane glycerolipid pools represents the key regulatory step in cellular responses to various stimuli, such as growth factors, cytokines, chemokines and circulating hormones. Released AA is metabolized via cyclo-oxygenase (COX 1 COX 2), lipoxygenase (LOX) or P450-dependent epoxygenase pathways generate eicosanoids. In addition their normal biological activities, stimulation mitogenesis motility, eicosanoids have also been postulated contribute tumorigenesis progression certain tumor cells. Various metabolites implicated a variety growth-related signaling involving ras (Han et al. 1991), interferon-α, epithelial factor (EGF), cyclic adenosine monophosphate, protein kinase C (PKC; Hannigan Williams 1991; Peppelenbosch 1993; Tang 1995a), mitogen-activated kinases (Rao 1988) fos (Danesch 1994). Numerous studies demonstrated strong correlation between growth-factor-promoted cell proliferation generation products, primarily prostaglandins (Nolan 1988).
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