Incorporation of chitosan nanospheres into thin mineralized collagen coatings for improving the antibacterial effect.

摘要: Abstract It is desired that the coatings on metallic implants have both excellent biological responses and good loading-release capacities of factors or drugs. So far, challenge still remains, because morphology composition bioactive are usually not favorable for accommodating drug molecules. In this study, we adopted an approach incorporating chitosan nanospheres into a thin mineralized collagen coating; based loading–release behavior cytocompatibility coating. The incorporation was realized by electrolytic co-deposition. morphologies microstructures resulting were characterized SEM, phase chemical compositions measured XRD FTIR. capacity vancomycin hydrochloride (VH) determined ultraviolet spectrophotometry. MTS assay used to evaluate cytocompatibility, in vitro bacterial adhesion tested assessing antibacterial effects VH-loaded coatings. adhered tightly fibrils. incorporated facilitated sustained release VH, had clear effect. demonstrates effective way improve This formulation highly response.