Advances in understanding and use of autoantibodies as markers of diseases

摘要: Human autoantibodies have a significant place in the history of clinical and molecular medicine. First, dating to original observations LE cell 1948 (Hargraves et al. 1948) present-day applications array analyses, their use as diagnostic prognostic markers disease has been valuable adjunct medicine (Tan 1991,(1999). Second, role pathogenesis provided some useful approaches therapy (G. Hahn 1986, B. etal. 2001). Third, impact felt field biology, where human opened new fields study resulted incremental knowledge through reagents discover understand function novel cellular compartments 1991, von Muhlen Tan 1995, Fritzler 1996). Small nuclear ribonucleoproteins (snRNPs) splicesome Lerner Steitz 1981), unique centromere/kinetochore (Earnshaw Rothfield 1985, Rattner 1995), nucleolar (Reimer 1987, 1993), Golgi complex (Chan 1998), endosome (Selak 1999, Waite 1998) proteins were all elucidated autoantibodies.