Analyses of human–chimpanzee orthologous gene pairs to explore evolutionary hypotheses of aging
作者： João Pedro de Magalhães , George M. Church
DOI: 10.1016/J.MAD.2007.03.004
关键词: Genetics 、 Gene 、 Longevity 、 Senescence 、 Comparative genomics 、 Model organism 、 Negative selection 、 Orthologous Gene 、 Natural selection 、 Biology 、 Developmental biology 、 Ageing
摘要: Compared to chimpanzees (Pan troglodytes), the onset of aging appears be delayed in human species. Herein, we studied human– chimpanzee orthologous gene pairs investigate selective forces acting on genes associated with different model systems, which allowed us explore evolutionary hypotheses aging. Our results show that aging-associated tend under purifying selection and stronger-than-average functional constraints. We found little evidence accelerated evolution hominid or lineages, pathways previously related were largely conserved between humans chimpanzees. In particular, non-mammalian organisms cellular systems appear stronger constraints than those mammals. One might have undergone rapid hominids is Werner syndrome gene. Overall, our findings offer novel insights regarding systems. propose may part pleiotropic effects not regulate species differences # 2007 Elsevier Ireland Ltd. All rights reserved.
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