Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus.

摘要: Current therapy of chronic hepatitis C is based on the combination pegylated interferon-α and ribavirin. In spite 50% sustained virological response, still limited by unsatisfying success rates with genotype 1 infections adverse side effects. One attempt to increase triple interferon ribavirin amantadine, a drug assumed interfere HCV p7 ion channel function. However, results from clinical trials indicate efficacy antiviral activity unclear. contrast, NS3 protease inhibitors have shown potent effects in but rapid selection for resistance may limit their benefit. Targeting cellular factors required therefore an attractive alternative. this study, employing system production infectious particles cell culture, we determined amantadine iminosugar derivatives; second which primarily target host glucosidases folding maturation envelope glycoproteins. We found that across spectrum isolates genotypes, affected neither RNA replication nor release or infectivity particles. agreement, was not demonstrating HCV-selective antiviral. dose-dependent reduction virus titers achieved iminosugars. Furthermore, rapidly eliminated culture upon passage presence long alkyl chain deoxynojirimycin (DNJ). Conclusion: Iminosugar derivatives are potential drugs treatment infections. (HEPATOLOGY 2007.)