Electrophysiology and cytology of hippocampal formation transplants in the anterior chamber of the eye. I. Intrinsic organization.

摘要: Summary Pieces of the immature hippocampal formation were transplanted to anterior chamber adult rat eyes. The transplants survived, became vascularized from host irides, and proliferated extensively in proportion age donor fetus. These mature develop an organization oculo. This maturation proceeds unimpaired absence gyrus dentatus or after superior cervical ganglionectomy. various strata normal hippocampus could be readily identified cytologically transplants. Surface electrical stimulation elicited negative positive field potentials at depths transplant. associated with excitation inhibition pyramidal neurons respectively. Much shown orthodromic nature. In contrast situ findings, however, cells oculo had negligible spontaneous activity. It is concluded that local excitatory inhibitory pathways any extrahippocampal afferents. Moreover, overall high degree cytological electrophysiological suggests many regulatory factors are intrinsic do not require neural input.