The action of norepinephrine in the rat hippocampus. I. Iontophoretic studies
作者： Menahem Segal , Floyd E. Bloom
DOI: 10.1016/0006-8993(74)90652-0
关键词:
摘要: Abstract The cellular responses to iontophoretic application of norepinephrine (NE) and related compounds were tested in the hippocampus rat. majority cells inhibited during shortly after NE. NJ-1999, a beta adrenergic antagonist, blocked this response NE while DMI, an agent which inhibits uptake by fibers potentiated response. Cells 6-hydroxydopamine-treated rats fired faster than those normal more sensitive Cyclic AMP its dibutyryl derivative produced NE-like inhibitions. was partially concurrent iontophoresis prostaglandins E series, enhanced phosphodiesterase inhibitor, papaverine. It is suggested that neurotransmitter candidate it may act via cyclic system.
elsevier.com
sci-hub.se 参考文章(51)
R. Fumagalli, V. Bernareggi, F. Berti, M. Trabucchi, Cyclic AMP formation in human brain: an in vitro stimulation by neurotransmitters. Life Sciences. ,vol. 10, pp. 1111- 1115 ,(1971) , 10.1016/0024-3205(71)90229-3
Tomas Hökfelt, Åke Ljungdahl, Modification of the Falck-Hillarp formaldehyde fluorescence method using the Vibratome: simple, rapid and sensitive localization of catecholamines in sections of unfixed or formalin fixed brain tissue Histochemistry and Cell Biology. ,vol. 29, pp. 325- 339 ,(1972) , 10.1007/BF00279815
Ch. Stumpf, Drug action on the electrical activity of the hippocampus. International Review of Neurobiology. ,vol. 8, pp. 77- 138 ,(1965) , 10.1016/S0074-7742(08)60756-4
P. M. Lish, J. H. Weikel, K. W. Dungan, Pharmacological and toxicological properties of two new beta-adrenergic receptor antagonists. Journal of Pharmacology and Experimental Therapeutics. ,vol. 149, pp. 161- 173 ,(1965)
W. R. Kukovetz, G. P�ch, Inhibition of cyclic-3',5'-nucleotide-phosphodiesterase as a possible mode of action of papaverine and similarly acting drugs. Naunyn-Schmiedebergs Archiv f�r Pharmakologie. ,vol. 267, pp. 189- 194 ,(1970) , 10.1007/BF00999402
H.M Geller, D.J Woodward, An improved constant current source for micro-iontophoretic drug application studies Electroencephalography and Clinical Neurophysiology. ,vol. 33, pp. 430- 432 ,(1972) , 10.1016/0013-4694(72)90125-3
A. Herz, A.C. Nacimiento, Über die Wirkung von Pharmaka auf Neurone des Hippocampus nach mikroelektrophoretischer Verabfolgung Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 250, pp. 258- 259 ,(1965) , 10.1007/BF00246991
G. R. Siggins, E. F. Battenberg, B. J. Hoffer, F. E. Bloom, A. L. Steiner, Noradrenergic Stimulation of Cyclic Adenosine Monophosphate in Rat Purkinje Neurons: An Immunocytochemical Study Science. ,vol. 179, pp. 585- 588 ,(1973) , 10.1126/SCIENCE.179.4073.585
H. Vapaatalo, P. Anttila, Effects of some inhibitors of phosphodiesterase on neuromuscular transmission Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 275, pp. 227- 232 ,(1972) , 10.1007/BF00508910
B.J. Hoffer, G.R. Siggins, F.E. Bloom, Studies on norepinephrine-containing afferents to Purkinje cells of rat cerebellum. II. Sensitivity of Purkinje cells to norepinephrine and related substances administered by microiontophoresis Brain Research. ,vol. 25, pp. 523- 534 ,(1971) , 10.1016/0006-8993(71)90458-6