An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.
作者： Birgit Knoechel , Justine E Roderick , Kaylyn E Williamson , Jiang Zhu , Jens G Lohr
DOI: 10.1038/NG.2913
关键词: Targeted therapy 、 Regulation of gene expression 、 Cell culture 、 Drug resistance 、 Signal transduction 、 Epigenetics 、 Immunology 、 T cell 、 Biology 、 Chromatin
摘要: Michelle Kelliher, Bradley Bernstein and colleagues identify T cell acute lymphoblastic leukemia cells that are resistant to γ-secretase inhibitor treatment characterize the epigenetic mechanism of resistance.
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